The table below lists articles in peer-reviewed journals authored by ACCRF-funded investigators.
Date ACCRF PI(s) Title/Subject Journal PubMed 2020 Feb 14 Morris, Ho, Chan, Wong The immune microenvironment and neoantigen landscape of aggressive salivary gland carcinomas differ by subtype. Clin Cancer Res 32060100 2020 Jan 31 Klempnauer, Stenman Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells. Cancer Lett 32014461 2020 Jan 30 Baujat, Atallah Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study. Eur J Cancer 32008920 2020 Jan 23 Faquin PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications. Ophthalmic Plast Reconstr Surg 31990894 2019 Oct 14 van Herpen Advances and challenges in precision medicine in salivary gland cancer. Cancer Treat Rev 31644971 2019 Sep 4 Morris, Chan, Schultz, Ho, Weigelt, Reis-Filho, El-Naggar, Futreal, Agrawal, Ha Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest 31483290 2019 Jul 10 Ramsay First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427). Contemp Clin Trials Commun 31650066 2019 Apr 22 Morris, Chan, Ho Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat Med 31011208 2019 Apr 2 Ho Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. J Clin Oncol 30939095 2019 Apr 1 Bakst Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer. Int J Radiat Oncol Biol Phys 30562546 2019 Mar Moskaluk, Agarwal Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation. EBioMedicine 30765319 2018 Oct 18 Nor, Castilho UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line. Oral Oncol 30527239 2018 Sep 12 Zon, Knoechel, Wick Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med 30209067 2018 May 3 Ferrarotto A Phase 1 dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors. Ann Oncol 29726923 2018 Mar 19 Jimeno, Reyland Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression. Clin Cancer Res 29555661 2018 Jan 9 Knoechel Peptidomimetic blockade of MYB in acute myeloid leukemia. Nat Commun 29317678 2017 Dec 28 Weigelt, Reis-Filho MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. J Pathol 29149504 2017 Dec 23 Ness, El-Naggar Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes. Oncotarget 29484115 2017 Nov 15 Bakst, Wong Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res 28951461 2017 Nov Aster, Faquin Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol 28914715 2017 Sep 14 Ferrarotto Taking it up a NOTCH: a novel subgroup of ACC is identified. Oncotarget 29137213 2017 Sep 12 Agarwal, Moskaluk, Wick A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug. Sci Rep 28900283 2017 May 26 El-Naggar, Futreal, Mitani Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst 29117356 2017 May 22 Stenman, Wick Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling. J Natl Cancer Inst 28954282 2017 May Ivanov, Yarbrough, Moskaluk MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma. Stem Cell Res 28500913 2017 Apr 8 Castilho, Nor Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence. Stem Cell Res 28426972 2017 Apr 4 Moskaluk A Phase II study of Dovitinib in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Clin Cancer Res 28377480 2017 Mar 22 LoRusso, Goncalves A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma. Oncotarget 28415633 2017 Mar 1 Wick A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors. Clin Cancer Res 27733479 2017 Feb 15 Nor Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res 27550999 2017 Jan 27 Ivanov, Yarbrough Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers. Clin Breast Cancer 28216417 2017 Jan 20 Ferrarotto, Mitani, El-Naggar, Futreal, Wick Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. Clin Cancer Res 27870570 2016 Dec Klempnauer Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells. Mol Cancer Ther 27707899 2016 Oct Ho, Morris A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma. Ann Oncol 27566443 2016 Sep 10 Faquin Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall. Am J Clin Pathol 27614667 2016 Aug 14 Brait, Ha Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget 27312343 2016 Aug 5 Weigelt, Reis-Filho Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. Mod Pathol 27491809 2016 Aug 4 Yarbrough, Ivanov Clinical and molecular insights into adenoid cystic carcinoma: Neural crest-like stemness as a target. Laryngoscope Investig Otolaryngol 28894804 2016 Aug Sala Cutaneous cylindroma: it’s all about MYB. Cancer Immunol Res 27185061 2016 Aug Schoenfeld, Dranoff, El-Naggar Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes. Cancer Immunol Res 27312343 2016 Jul 21 Morris, Ho, Chan The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform. JAMA Oncol 27442865 2016 Jul Ha, Wick, Fertig, Brait Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol 27212063 2016 Jun Li Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors. Ann Diagn Pathol 27180058 2016 May 18 Wong The impact of the MYB-NFIB fusion protooncogene in vivo. Oncotarget 27213588 2016 May Ferrarotto MYB-fusions and other potential actionable targets in adenoid cystic carcinoma. Curr Opin Oncol 26974847 2016 Apr 15 Ivanov, Yarbrough NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res 27084744 2016 Mar 2 Nor, Moskaluk, Wick Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res 26936915 2016 Feb Gonda, Ramsay Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology. Cancer Discov 26851182 2016 Feb 9 Ha, Agrawal Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res 26862087 2016 Feb 1 Bernstein, Knoechel, El-Naggar, Moskaluk, Aster, Faquin, Wick, Queimado An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 26829750 2015 Dec 2 Ness Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma. Cancer Discov 26631070 2015 Dec 2 El-Naggar Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res 26631609 2015 Dec 2 Klempnauer Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction. Blood 26631113 2015 Nov 17 Mapp Targeting transcription is no longer a quixotic quest. Nat Chem Biol 26575226 2015 Jun 26 Nor BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol 26121939 2015 Jun 16 Dillon, Thomas, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882 2015 Jun 12 Weigelt, Reis-Filho, Chan, Stenman Genomic landscape of adenoid cystic carcinoma of the breast. J Pathol 26095796 2015 Jun 5 Stenman Detection of MYB Alterations and Other Immunohistochemical Markers in Primary Cutaneous Adenoid Cystic Carcinoma. Am J Surg Pathol 26076064 2015 Jun 3 El-Naggar Analysis and significance of c-MET expression in adenoid cystic carcinoma of the salivary gland. Cancer Biol Ther 25923130 2015 Jun Klempnauer Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300. Mol Cancer Ther 25740244 2015 May 8 Weigelt, Reis-Filho Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing. Histopathology 25951887 2015 May Ha MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Laryngoscope 25963073 2015 Apr Ramsay MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region. PLoS One 25853889 2015 Feb Weigelt, Reis-Filho The birth of an adenoid cystic carcinoma. Int J Surg Pathol 25185745 2015 Jan 9 Ramsay Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein. Clin Transl Immunology 25671128 2014 Dec Kaye, El-Naggar A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget 25587024 2014 Dec Thomas, Dillon, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882 2014 Nov-Dec Bakst A contouring guide for head and neck cancers with perineural invasion. Pract Radiat Oncol 25407876 2014 Oct El-Naggar Development and characterization of salivary adenoid cystic carcinoma cell line. Oral Oncol 25086988 2014 Oct Aster, Bernstein, Knoechel, Moskaluk Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 25104330 2014 Aug Stenman Diagnostic and therapeutic implications of new molecular biomarkers in salivary gland cancers. Oral Oncol 24856188 2014 May 22 Queimado Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis. 24853424 2014 Apr Pusztaszeri, Faquin MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens. Cancer Cytopathol 24302647 2014 Feb El-Naggar Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diag Pathol 24238845 2014 Feb Ha Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngology Head Neck Surg 24493792 2014 Feb Stenman Primary sinonasal adenoid cystic carcinoma presenting with skin metastases–genomic profile and expression of the MYB-NFIB fusion biomarker. Histopathology 24410806 2013 Oct Stenman Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics. Ophthalmology 23725736 2013 Sep 15 Moskaluk Sinonasal tract and nasopharyngeal adenoid cystic carcinoma: a clinicopathologic and immunophenotypic study of 86 cases. Head Neck Pathol 24037641 2013 Sep Nor Salivary gland cancer stem cells. Oral Oncol 23810400 2013 Aug 8 Yarbrough TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene 23027130 2013 Aug El-Naggar, Stenman The 3rd Salivary Gland Tumor Workshop meeting report. Head Neck 23677839 2013 Jul 23 Yarbrough, Ivanov Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer 23799842 2013 Jul 1 Moskaluk Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming. J Clin Invest 23778135 2013 Jul 1 Futreal,El-Naggar Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest 23778141 2013 Jul Chan The mutational landscape of adenoid cystic carcinoma. Nat Genet 23685749 2013 Jun 25 El-Naggar MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLos One 23825564 2013 Jun El-Naggar Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol. 23583282 2013 Mar Moskaluk Adenoid cystic carcinoma: clinical and molecular features. Head Neck Pathol. 23463073 2013 Mar Stenman Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology 23398044 2012 Nov 7 Ha Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma. PLoS One 23144906 2012 Nov Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498 2012 Aug 15 El-Naggar A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer 22179977 2012 Aug Stenman Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. Genes Chromosomes Cancer 22505352 2012 Mar El-Naggar Developmental transcription factor EN1–a novel biomarker in human salivary gland adenoid cystic carcinoma. Cancer 21800291 2012 Jan Stenman Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. Int J Oncol 21901247 2011 Nov 15 El-Naggar, Futreal Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB-NFIB Chimeric Fusion, MYB Expression, and Clinical Outcome. Clin Cancer Res 21976542 2011 Oct 21 El-Naggar Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 22020577 2011 Oct 17 Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498 2011 Oct 1 El-Naggar Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 21785271 2011 Oct Moskaluk Development and characterization of xenograft model systems for adenoid cystic carcinoma. Lab Invest 21709671 2011 Sep Moskaluk, Stenman Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 21572406 2011 Jul 28 El-Naggar Developmental transcription factor EN1-a novel biomarker in human salivary gland adenoid cystic carcinoma Cancer 21800291 2011 Jul 1 El-Naggar CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Cancer 21692051 2011 Jul 1 Ha, Moskaluk Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res 21551254 2011 Jul Stenman The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol 21618541 2011 Apr Ha Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol 21324728 2010 Dec 15 El-Naggar Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 20824717 2010 Oct 1 El-Naggar Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res 20702610 2010 Aug 1 Stenman New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer. Cell Cycle 20647765 2010 Jun Moskaluk, Futreal, El-Naggar C-kit gene mutations in adenoid cystic carcinoma are rare. Mod Pathol 20514080 2009 Dec 30 Ha, El-Naggar Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One 20041111 2009 Nov 3 Stenman Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. PNAS 19841262 2009 Aug 26 Kirsch Perineural invasion detected by high-field 3.0-T magnetic resonance imaging. Am J Otolaryngol 20015797 2008 Aug 15 El-Naggar Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res 18698036