• Published Papers

    The table below lists articles in peer-reviewed journals authored by ACCRF-funded investigators.

    Date ACCRF PI(s) Title/Subject Journal PubMed
    2016 Oct Ho, Morris A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma. Ann Oncol 27566443
    2016 Sep 10 Faquin Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall. Am J Clin Pathol 27614667
    2016 Aug 5 Weigelt, Reis-Filho Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. Mod Pathol 27491809
    2016 Aug 14 Brait, Ha Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget 27312343
    2016 Aug Schoenfeld, Dranoff Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes. Cancer Immunol Res 27312343
    2016 Jul 21 Morris, Ho, Chan The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform. JAMA Oncol 27442865
    2016 Jul Ha, Wick, Fertig, Brait Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol 27212063
    2016 Jun Li Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors. Ann Diagn Pathol 27180058
    2016 May 18 Wong The impact of the MYB-NFIB fusion protooncogene in vivo. Oncotarget 27213588
    2016 May Ferrarotto MYB-fusions and other potential actionable targets in adenoid cystic carcinoma. Curr Opin Oncol 26974847
    2016 Apr 15 Ivanov, Yarbrough NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res 27084744
    2016 Mar 2 Nor Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res 26936915
    2016 Feb Gonda, Ramsay Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology. Cancer Discov 26851182
    2016 Feb 9 Ha, Agrawal Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res 26862087
    2016 Feb 1 Bernstein, Knoechel, El-Naggar, Moskaluk, Aster, Faquin, Wick, Queimado An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 26829750
    2015 Dec 2 Ness Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma. Cancer Discov 26631070
    2015 Dec 2 El-Naggar Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res 26631609
    2015 Dec 2 Klempnauer Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction. Blood 26631113
    2015 Nov 17 Mapp Targeting transcription is no longer a quixotic quest. Nat Chem Biol 26575226
    2015 Jun 26 Nor BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol 26121939
    2015 Jun 16 Dillon, Thomas, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882
    2015 Jun 12 Weigelt, Reis-Filho, Chan, Stenman Genomic landscape of adenoid cystic carcinoma of the breast. J Pathol 26095796
    2015 Jun 5 Stenman Detection of MYB Alterations and Other Immunohistochemical Markers in Primary Cutaneous Adenoid Cystic Carcinoma. Am J Surg Pathol 26076064
    2015 Jun 3 El-Naggar Analysis and significance of c-MET expression in adenoid cystic carcinoma of the salivary gland. Cancer Biol Ther 25923130
    2015 Jun Klempnauer Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300. Mol Cancer Ther 25740244
    2015 May 8 Weigelt, Reis-Filho Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing. Histopathology 25951887
    2015 May Ha MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Laryngoscope 25963073
    2015 Apr Ramsay MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region. PLoS One 25853889
    2015 Feb Weigelt, Reis-Filho The birth of an adenoid cystic carcinoma. Int J Surg Pathol 25185745
    2014 Dec Kaye, El-Naggar A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget 25587024
    2014 Dec Thomas, Dillon, Moskaluk Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 25487882
    2014 Nov-Dec Bakst A contouring guide for head and neck cancers with perineural invasion. Pract Radiat Oncol 25407876
    2014 Oct El-Naggar Development and characterization of salivary adenoid cystic carcinoma cell line. Oral Oncol 25086988
    2014 Oct Aster, Bernstein, Knoechel, Moskaluk Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 25104330
    2014 Aug Stenman Diagnostic and therapeutic implications of new molecular biomarkers in salivary gland cancers. Oral Oncol 24856188
    2014 May 22 Queimado Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis. 24853424
    2014 Apr Pusztaszeri, Faquin MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens. Cancer Cytopathol 24302647
    2014 Feb El-Naggar Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diag Pathol 24238845
    2014 Feb Ha Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngology Head Neck Surg 24493792
    2014 Feb Stenman Primary sinonasal adenoid cystic carcinoma presenting with skin metastases–genomic profile and expression of the MYB-NFIB fusion biomarker. Histopathology 24410806
    2013 Oct Stenman Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics. Ophthalmology 23725736
    2013 Sep 15 Moskaluk Sinonasal tract and nasopharyngeal adenoid cystic carcinoma: a clinicopathologic and immunophenotypic study of 86 cases. Head Neck Pathol 24037641
    2013 Sep Nor Salivary gland cancer stem cells. Oral Oncol 23810400
    2013 Aug 8 Yarbrough TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene 23027130
    2013 Aug El-Naggar, Stenman The 3rd Salivary Gland Tumor Workshop meeting report. Head Neck 23677839
    2013 Jul 23 Yarbrough, Ivanov Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer 23799842
    2013 Jul 1 Moskaluk Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming. J Clin Invest 23778135
    2013 Jul 1 Futreal,El-Naggar Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest 23778141
    2013 Jul Chan The mutational landscape of adenoid cystic carcinoma. Nat Genet 23685749
    2013 Jun 25 El-Naggar MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLos One 23825564
    2013 Jun El-Naggar Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol. 23583282
    2013 Mar Moskaluk Adenoid cystic carcinoma: clinical and molecular features. Head Neck Pathol. 23463073
    2013 Mar Stenman Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology 23398044
    2012 Nov 7 Ha Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma. PLoS One 23144906
    2012 Nov Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498
    2012 Aug 15 El-Naggar A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer 22179977
    2012 Aug Stenman Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. Genes Chromosomes Cancer 22505352
    2012 Mar El-Naggar Developmental transcription factor EN1–a novel biomarker in human salivary gland adenoid cystic carcinoma. Cancer 21800291
    2012 Jan Stenman Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. Int J Oncol 21901247
    2011 Nov 15 El-Naggar, Futreal Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB-NFIB Chimeric Fusion, MYB Expression, and Clinical Outcome. Clin Cancer Res 21976542
    2011 Oct 21 El-Naggar Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 22020577
    2011 Oct 17 Ha Molecular biology of adenoid cystic carcinoma. Head Neck 22006498
    2011 Oct 1 El-Naggar Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 21785271
    2011 Oct Moskaluk Development and characterization of xenograft model systems for adenoid cystic carcinoma. Lab Invest 21709671
    2011 Sep Moskaluk, Stenman Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 21572406
    2011 Jul 28 El-Naggar Developmental transcription factor EN1-a novel biomarker in human salivary gland adenoid cystic carcinoma Cancer 21800291
    2011 Jul 1 El-Naggar CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Cancer 21692051
    2011 Jul 1 Ha, Moskaluk Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res 21551254
    2011 Jul Stenman The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol 21618541
    2011 Apr Ha Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol 21324728
    2010 Dec 15 El-Naggar Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 20824717
    2010 Oct 1 El-Naggar Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res 20702610
    2010 Aug 1 Stenman New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer. Cell Cycle 20647765
    2010 Jun Moskaluk, Futreal, El-Naggar C-kit gene mutations in adenoid cystic carcinoma are rare. Mod Pathol 20514080
    2009 Dec 30 Ha, El-Naggar Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One 20041111
    2009 Nov 3 Stenman Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. PNAS 19841262
    2009 Aug 26 Kirsch Perineural invasion detected by high-field 3.0-T magnetic resonance imaging. Am J Otolaryngol 20015797
    2008 Aug 15 El-Naggar Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res 18698036